ACTSI Investigator Dr. Roy Sutliff in the News

Roy Sutliff, PhD is an ACTSI investigator and associate professor in the Emory’s Division of Pulmonary, Allergy and Critical Care Medicine based at the Atlanta VA Medical Center. Research in his laboratory focuses on the role of oxidative stress in the development of cardiovascular and pulmonary diseases. The major focus is studying the impact of HIV-1 proteins on superoxide enzymatic sources and antioxidant systems and how the effects of HIV-1 proteins on these enzymes affect cardiovascular and pulmonary function. In his free time, he enjoys spending time with family and working on the home he and his wife designed and built.

Recent Funding:
The Department of Defense funded Sutliff’s proposal, “Development of Novel Rho Kinase Inhibitors for Treatment of Pulmonary Hypertension,” through the end of 2016. The goal of this proposal is to develop novel orally active, once-per-day, Rho-kinase inhibitors that will significantly improve treatment of pulmonary hypertension and blunt pulmonary vascular changes that lead to morbidity and mortality. The work will be in collaboration with Anacor Pharmaceuticals Inc, Palo Alto, CA.

Sutliff received an R21 award from NIH for his project entitled, “Role of Oxido-reductive Stress in Regulating HIV-TB Coinfection.”

Publications:
“Pro-Atherogenic Shear Stress and HIV Proteins Synergistically Upregulate Cathepsin K in Endothelial Cells” Annals of Biomedical Engineering. 2014 Jun. Read more…

“Chronic Hypoxia Promotes Pulmonary Artery Endothelial Cell Proliferation through H2O2-Induced 5-Lipoxygenase.” PLoS One. 2014; 9(6): e98532. 

“Polymerase delta interacting protein 2 sustains vascular structure and function” Arterioscler Thromb Vasc Biol. 2013 Sep. Read more…

“Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.” Transfusion 2013 Mar 11. doi: 10.1111/trf.12111. [Epub ahead of print]